Chapter 16: Prophylactic Human Papillomavirus Vaccines
نویسندگان
چکیده
منابع مشابه
Prophylactic human papillomavirus vaccines.
Human papillomavirus (HPV) infection causes virtually all cases of cervical cancer, the second most common cause of death from cancer among women worldwide. This Review examines prophylactic HPV subunit vaccines based on the ability of the viral L1 capsid protein to form virus-like particles (VLPs) that induce high levels of neutralizing antibodies. Following preclinical research by laboratorie...
متن کاملChapter 7 Therapeutic Human Papillomavirus ( HPV ) Vaccines
Cervical cancer trends to occur in midlife. Most cases are found in women younger than 50. More than 15% of cases of cervical cancer are found in women over 65 but, these cancers rarely arrise in women who have regular tests for cervical cancer screening before they were 65. The most important etiological factor in cervical cancer and precursor lesions is persistent infection by HPV. Thus, an e...
متن کاملHuman Papillomavirus Prophylactic Vaccines and Alternative Strategies for Prevention
First evidence that transmissible agents are involved in the development of cervical cancer dates back to the mid 19th century and is based on investigations of the Italian physi‐ cian Demonico Rigoni-Stern who recognized that cancer of the womb is found most frequently among women in their fourth and fifth decade and that factors such as age of sexual debut and promiscuity attribute to the ris...
متن کاملHuman papillomavirus-associated cervical cancer: Prophylactic and therapeutic vaccines
Abbreviations: Adeno-associated virus, (AAV); bacilli Calmette-Guerin, (BCG); base pairs, (bp); cottontail rabbit papilloma virus, (CRPV); E6-associated protein, (E6-AP); epidermal growth factor receptor, (EGFR); histone deacetylases, (HDAC); human papillomavirus, (HPV); inverted terminal repeats, (ITRs); listerolysin O, (LLO); of lysosome-associated membrane protein, (LAMP); open reading frame...
متن کاملChapter 12: Prophylactic HPV vaccines: underlying mechanisms.
Human papillomavirus virus-like particles (HPV VLP) can be generated by the synthesis and self-assembly in vitro of the major virus capsid protein L1. HPV L1 VLPs are morphologically and antigenically almost identical to native virions, and this technology has been exploited to produce HPV L1 VLP subunit vaccines. The vaccines elicit high titres of anti-L1 VLP antibodies that persist at levels ...
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ژورنال
عنوان ژورنال: JNCI Monographs
سال: 2003
ISSN: 1052-6773,1745-6614
DOI: 10.1093/oxfordjournals.jncimonographs.a003472